Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites
R. Roessner, N. Michelarakis, F. Gräter, C. Aponte-Santamaria
This study shows mechanical forces increase VAR2CSA's binding avidity by converting it from monovalent to multivalent through conformational changes exposing additional CSA binding sites.
bioRxiv · Jul 31, 2023Biophysics