Deep learning-based prediction of enzyme optimal pH and design of point mutations to improve acid resistance
Sizhe Qiu, Nan-Kai Wang, Yishun Lu, Jin‐Song Gong, Jin‐Song Shi, Aidong Yang
This study introduces CatOpt, a deep learning model that predicts enzyme optimal pH and designs point mutations to improve acid resistance, achieving a 7% activity increase in a specific enzyme.
ACS Synthetic Biology · Nov 21, 2025Peer-reviewedBioinformatics