Dose-dependent, opioid-induced sleep disruption is partially mediated by motor activity but not by body temperature in C57BL/6J mice
Diana Zebadúa Unzaga, Christopher OʼBrien, Natania W. Cooper, Charlie E. Olson, Xiaojuan Zhu, Michael A. O’Neil, Joshua M. Price, Ralph Lydic, Helen A. Baghdoyan
This study shows that low doses of fentanyl and morphine cause sleep disruption in mice, partially mediated by motor activity but not body temperature.
Journal of Pharmacology and Experimental Therapeutics · Sep 11, 2025Peer-reviewedPharmacology & Toxicology