Cell-Type-Resolved Isoform Atlas of Human Tissues Reveals Age and Alzheimer's Disease-Associated Splicing Changes
Ryo Yamamoto, Ting Fu, Elaine Huang, Anna Fraser, Nazim Mohammad, Xinshu Grace Xiao, Noah Zaitlen
The paper introduces Sciege, a method to estimate cell type-specific isoform distributions using bulk and single-cell RNA-seq data, revealing age and Alzheimer's disease-related splicing changes.
bioRxiv · Nov 14, 2025 · PreprintBioinformatics