Leishmania major centrin knock-out parasites alter the Kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory response
Timur Oljuskin, Nazli Azodi, Greta Volpedo, Parna Bhattacharya, Nevien Ismail, Shinjiro Hamano, Greg Matlashewski, Abhay R. Satoskar, Sreenivas Gannavaram, Hira Lal Nakhasi
This study shows that Leishmania major centrin knock-out parasites alter host tryptophan metabolism to reduce kynurenine-AhR signaling and induce a pro-inflammatory response.
bioRxiv · Sep 15, 2022 · PreprintSystems Biology