The Okur-Chung Neurodevelopmental Syndrome (OCNDS) mutation CK2K198R leads to a rewiring of kinase specificity
Danielle Caefer, Nhat Q. Phan, Jennifer C. Liddle, Jeremy Lynn Balsbaugh, Joseph P O’Shea, Anastasios V. Tzingounis, Daniel Schwartz
The paper investigates the impact of the OCNDS-associated CK2K198R mutation on kinase specificity, finding it shifts substrate preferences rather than causing loss of function.
Frontiers in Molecular Biosciences · Apr 19, 2022Peer-reviewedNeuroscience