Cellular reprogramming of human monocytes is regulated by time-dependent IL4 signalling and NCOR2
Jil Sander, Susanne V. Schmidt, Branko Cirovic, Naomi McGovern, Olympia Papantonopoulou, Anna-Lena Hardt, Anna C. Aschenbrenner, Christoph Kreer, Kreer Quast, Alexander M. Xu, Lisa M. Schmidleithner, Heidi Theis, Thi Huong Lan Do, Hermi Rizal Bin Sumatoh, Mario A. R. Lauterbach, , Joachim L. Schultze
This study investigates how IL4 signalling and NCOR2 regulate the reprogramming of human monocytes into dendritic cells and macrophages, revealing distinct transcriptional and functional profiles based on cytokine exposure timing.
bioRxiv · Oct 16, 2017 · PreprintImmunology