Nicholas A. Melosh

Ultra-sensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes

The paper measures insertion mechanics and vascular responses of microscale neural probes in vivo, finding constant insertion force post-pia penetration and vessel displacement avoiding rupture at small scales.

Direct-print three-dimensional electrodes for large-scale, high-density, and customizable neural interfaces

The paper presents a method for fabricating 3D microelectrode arrays to interface with neural structures, demonstrating high-resolution recording from retinal ganglion cells.

CHIME: CMOS-hosted in-vivo microelectrodes for massively scalable neuronal recordings

The paper introduces CHIME, a scalable neuronal recording system using microwires and CMOS arrays to overcome limitations in capturing neural activity in mammalian brains.

Massively Parallel Microwire Arrays Integrated with CMOS chips for Neural Recording

The paper introduces a neural recording system combining microwire arrays with CMOS chips to enable high-density, three-dimensional neural interfaces.

NeuroRoots, a bio-inspired, seamless Brain Machine Interface device for long-term recording.

NeuroRoots is a bio-inspired, multi-channel implant that enables long-term stable neural recording in rats, maintaining signal quality for at least 7 weeks.

Ultra-sensitive measurement of brain penetration with microscale probes for brain machine interface considerations

This study measures brain penetration forces and tissue compression using microscale probes to inform better brain-machine interface design.