Guiding the design of bacterial signaling interactions using a coevolutionary landscape
Ryan R. Cheng, Ellinor Haglund, Nicholas S. Tiee, Faruck Morcos, Herbert Levine, Joseph A. Adams, Patricia Ann Jennings, José N. Onuchic
This study uses a co-evolutionary landscape to select mutations in bacterial signaling proteins, showing improved efficiency in enhancing phosphotransfer activity compared to random mutagenesis.
bioRxiv · Jun 2, 2017 · PreprintBioinformatics