Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
Melissa Grant‐Peters, Aine Fairbrother-Browne, Amy R. Hicks, Boyi Guo, Regina Hertfelder Reynolds, Louise A. Huuki-Myers, Nick Eagles, Jonathan Brenton, Sonia García-Ruiz, Nicholas Wood, Sonia Gandhi, Kristen R. Maynard, Leonardo Collado‐Torres, Mina Ryten
The paper investigates ligand-receptor interactions (LRIs) in neurological diseases and finds that 96.8% of disease-associated LRIs are interconnected, highlighting their role in disease comorbidity and potential drug targets.
bioRxiv · Jun 15, 2024 · PreprintNeuroscience