Author

Nick Watts

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:whole-exome sequencing· 3 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Alexandra MacDonaldiD· 2 shared Amos D. KorczyniD· 2 shared Andrea Byrnes· 2 shared Annika Rademacher· 2 shared Anthony Guy MarsoniD· 2 shared Brigid M. ReganiD· 2 shared Caitlin A. BennettiD· 2 shared Catharine Freyer· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Alexandra MacDonaldORCID

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Author profile →

4 papers

Recent·Most cited

The Power of Partnership: Democratizing Genetic Prevalence to Empower Patient Advocacy

Samantha M. Baxter, Moriel Singer‐Berk, Carmen Glaze, Kathryn Russell, Riley H. Grant, Emily Groopman, J. H. Lee, Nick Watts, Jordan C. Wood, Michael Wilson, Rare As One Network, Heidi L. Rehm, Anne O’Donnell‐Luria

The paper estimates genetic prevalence for 22 autosomal recessive conditions using gnomAD data and develops a tool to democratize these calculations, highlighting the dynamic nature of prevalence estimates.

medRxiv · Mar 31, 2026 · PreprintGenetic & Genomic Medicine

Ultra-rare constrained missense variants in the epilepsies: Shared and specific enrichment patterns in neuronal gene-sets

Mahmoud Koko, Roland Krause, Thomas Sander, Dheeraj Reddy Bobbili, Michael Nothnagel, Patrick May, Holger Lerche, Yen‐Chen Anne Feng, Daniel P. Howrigan, Liam E. Abbott, Katherine C. Tashman, Felecia E. Cerrato, Tarjinder Singh, Henrike Heyne, Andrea Byrnes, , Christian Hengsbach

The paper analyzes ultra-rare variants in epilepsy patients to identify gene-set enrichment patterns and differential impacts in neuronal gene categories.

EBioMedicine · Sep 24, 2021Peer-reviewedGenomics

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Julia K. Goodrich, Moriel Singer‐Berk, Rachel Son, Abigail Sveden, Jordan C. Wood, Eleina M. England, Joanne B. Cole, Ben Weisburd, Nick Watts, Lizz Caulkins, Peter Dornbos, Ryan Koesterer, Zachary Zappala, Haichen Zhang, Kristin A. Maloney, , Kerrin S. Small

The paper evaluates penetrance and variable expressivity of monogenic metabolic conditions using exome data from 77,184 individuals, finding that monogenic variants have larger effect sizes than polygenic scores but low penetrance.

Nature Communications · Jun 9, 2021Peer-reviewedGenetic & Genomic Medicine

Ultra-rare genetic variation in the epilepsies: a whole-exome sequencing study of 17,606 individuals

Yen‐Chen Anne Feng, Daniel P. Howrigan, Liam E. Abbott, Katherine C. Tashman, Felecia E. Cerrato, Tarjinder Singh, Henrike Heyne, Andrea Byrnes, Claire L. Churchhouse, Nick Watts, Matthew Solomonson, Dennis Lal, Erin L. Heinzen, Ryan S. Dhindsa, Kate E. Stanley, , Ingo Borggräfe

This study identifies ultra-rare genetic variants associated with different epilepsy types using whole-exome sequencing in 17,634 individuals.

The American Journal of Human Genetics · Jul 18, 2019Peer-reviewedGenetics