The APOL1 variant p.N264K blocks ion flow by occluding a pore at the cell surface
Verena Höffken, Lara Console, Niklas Nelde, Hermann Pavenstädt, Cesare Indiveri, Thomas Weide
This study identifies how the APOL1 variant p.N264K prevents ion flow by blocking a pore, explaining its protective effect against kidney disease.
bioRxiv · Nov 5, 2025 · PreprintCell Biology