An explanatory benchmark of spatial domain detection reveals key drivers of method performance
Alice Descoeudres, Tomislav Prusina, Noah Schmidt, Van Hoan Do, Simon Mages, Johanna Klughammer, Domagoj Matijević, Stefan Canzar
This paper benchmarks 26 spatial domain detection methods across real and semi-synthetic spatial transcriptomics data to identify performance drivers and introduce a modular benchmarking framework.
bioRxiv · Mar 16, 2026 · PreprintBioinformatics