Insights into the biosynthesis of icumazole unveiling a distinctive family of crotonyl-CoA carboxylase/reductase
F. Xie, A. F. Kiefer, A. K. H. Hirsch, O. Kalinina, C. Fu, R. Mueller
The paper identifies a novel family of crotonyl-CoA carboxylase/reductase (CCR) enzymes involved in icumazole biosynthesis, revealing unique substrate specificity and cofactor usage.
bioRxiv · Nov 22, 2022Biochemistry