AlphaFold 2, but not AlphaFold 3, predicts confident but unrealistic beta-solenoid structures for repeat proteins
Olivia S. Pratt, Luc G. Elliott, Margaux Haon, Shahram Mesdaghi, Rebecca M. Price, Adam J. Simpkin, Daniel John Rigden
The paper evaluates AlphaFold 2's performance on repeat proteins, finding it predicts confident but unrealistic beta-solenoid structures, unlike other methods.
Computational and Structural Biotechnology Journal · Jan 1, 2025Peer-reviewedBioinformatics