Learning epistatic polygenic phenotypes with Boolean interactions
Merle Behr, Karl Kumbier, Aldo Córdova‐Palomera, Matthew Aguirre, Omer Ronen, Chengzhong Ye, Euan Angus Ashley, Atul Janardhan Butte, Rima Arnaout, Ben Brown, James Rush Priest, Bin Yu
The paper introduces epiTree, a pipeline using tree-based models to detect higher-order epistatic interactions in genomic data, validated on UK Biobank data for red hair and MS prediction.
PLoS ONE · Apr 16, 2024Peer-reviewedBioinformatics