A Hidden Markov Modeling Approach forIdentifying Tumor Subclones in Next-GenerationSequencing Studies
H. Choo-Wosoba, P. Albert, B. Zhu
This paper introduces subHMM, a hidden Markov model to estimate subclone regions, genotypes, and clonal proportions in tumor cells, applied to renal cell carcinoma data.
bioRxiv · Jun 20, 2019Cancer Biology