Role of Disulfide Bonds and Topological Frustration in the Kinetic Partitioning of Lysozyme Folding Pathways
A. N. Muttathukattil, P. C. N. Singh, G. Reddy
This paper shows that two disulfide bonds in lysozyme cause a slow folding pathway by trapping the protein in an intermediate state, which disappears when the bonds are removed.
bioRxiv · Jan 23, 2019Biophysics