Insights into the Polyhexamethylene Biguanide (PHMB) Mechanism of Action on Bacterial Membrane and DNA: A Molecular Dynamics Study
S. Sowlati-Hashjin, P. Carbone, M. Karttunen
This study uses molecular dynamics simulations to show PHMB does not form pores in bacterial membranes but instead binds to DNA, potentially blocking replication or activating repair.
bioRxiv · Mar 25, 2020Biophysics