Binding Position Dependent Modulation of Smoothened Activity by Cyclopamine
K. Kim, P. D. Bansal, D. Shukla
This study uses simulations to show cyclopamine acts as an agonist when bound to the CRD of Smoothened and as an antagonist when bound to the TMD, with mixed effects when bound to both sites.
bioRxiv · Feb 8, 2024 · PreprintBiophysics