Cuprizone drives divergent neuropathological changes in different mouse models of Alzheimer's disease
Gerald Wai‐Yeung Cheng, Iris Wai-Ting Ma, Jianpan Huang, Sunny Hoi‐Sang Yeung, Paolo Ho, Zilin Chen, Henry Ka‐Fung Mak, Karl Herrup, Kannie W. Y. Chan, Kai‐Hei Tse
This study investigates how cuprizone-induced demyelination affects two Alzheimer's disease mouse models, finding that myelin loss precedes amyloid deposition and may drive pathology.
bioRxiv · Jul 24, 2023 · PreprintNeuroscience