A modular generalist-specialist AI framework for ROI selection across spatial profiling workflow
Simón P. Castillo, Tanishq Gautam, K. Gonzales, Maria Esther Salvatierra, Alejandra Serrano, Caner Ercan, B. Leticia Rodriguez, Paul Acosta, Pingjun Chen, Yasin Shokrollahi, Alexandria Lau, Lawrence N. Kwong, Jason T. Huse, Xiaoxi Pan, Patient Mosaic Team, , Yinyin Yuan
The paper introduces a modular AI framework for ROI selection in spatial profiling, showing hybrid generalist-specialist strategies balance signal preservation, concordance, consistency, and efficiency.
bioRxiv · Jul 1, 2026 · PreprintPathology