Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system
Amirahmad Azhieh, Paul Hernandez, Alexander C. Anderson, David Sychantha, Adrian J. Verster, John C. C. Whitney, Benjamin D. Ross
The paper identifies rapidly evolving orphan immunity genes in human gut bacteria that protect against T6SS intoxication through high-affinity protein interactions and shows their evolutionary dynamics across microbiomes.
bioRxiv · May 3, 2025 · PreprintMicrobiology