Differences in the co-distribution of the Cannabinoid Receptor-1, FAAH, and MAGL in the human and mouse brain could be limiting clinical translation of endocannabinoid outcomes in mouse models of Alzheimer disease.
Ryan M. Heistad, Jennifer N.K. Nyarko, Paul R. Pennington, Huzaifa Saeed, Lais V.B. Gomes, Darrell D. Mousseau
The paper compares the distribution of CB1R, FAAH, and MAGL in human and mouse AD brains, finding species-specific differences that may affect the translatability of ECS findings in mouse models.
bioRxiv · Dec 12, 2025 · PreprintNeuroscience