Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition
Dina Schneidman‐Duhovny, Natalia Khuri, Guang Qiang Dong, Michael B. Winter, Eric Shifrut, Nir Friedman, Charles S. Craik, Kathleen P. Pratt, Pedro E. PAZ, Fred Aswad, Andrej Šali
This paper introduces ITCell, a method that predicts CD4 T-cell epitopes by integrating antigen cleavage, MHCII presentation, and TCR recognition, achieving higher accuracy than single-stage methods.
PLoS ONE · Nov 6, 2018Peer-reviewedBioinformatics