Comparative pangenomics of Trypanosoma brucei reveal host specialization is driven by targeted or segmental genome streamlining in human and equine-restricted lineages
Muyiwa Seyi Adegbaju, Olanrewaju B. Morenikeji, Prakash K Singh, Xiomara Lane, Olusola Daniel Ojurongbe, Bolaji N. Thomas
This paper investigates how Trypanosoma brucei adapts its genome during host specialization, revealing two distinct structural evolution pathways in human and equine-restricted lineages.
bioRxiv · Jun 19, 2026 · PreprintGenomics