Reconstructing clone-resolved transcriptional programs from bulk tumor sequencing
Jiaying Lai, Yi Yang, Kathleen Noller, YunZhou Liu, Archana Balan, Prathima B. Nagendra, Luciane Tsukamoto Kagohara, Elana Judith Fertig, Laura DeLong Wood, Rachel Karchin
PICTographPlus infers clone-resolved transcriptional programs from bulk RNA-seq by integrating clonal phylogenies and proportions, achieving high accuracy in recovering clone-level expression and localizing pathway changes.
bioRxiv · Jun 5, 2026 · PreprintGenomics