Mutational scan of self-cleavage by HIV-1 protease provides new views of a conformationally dynamic mechanism
Gily S. Nachum, Jeffrey I. Boucher, Julia M. Flynn, Princess Quansah, Sivan Nachum, Daniel N. A. Bolon
The paper identifies mutations that affect HIV-1 protease self-cleavage but not viral fitness, and uses simulations to model its dynamic mechanism.
Journal of Virology · Mar 31, 2026Peer-reviewedBiochemistry