Discovery of dynamic changes in 3D chromatin architecture through polymer physics model
Anubhooti, Abdul Wasim, Priyanka Kriti Narayan, Jagannath Mondal, Jagan M.R. Pongubala
The paper develops a polymer physics model to simulate 3D chromatin architecture dynamics in developing lymphoid cells, revealing structural changes linked to gene regulation and cell fate.
bioRxiv · Apr 11, 2024 · PreprintBioinformatics