Dissecting the Shared Genetic Architecture of Modifiable Physical Activity and Autoimmune Diseases
Minjing Chang, Kaixin Yao, Jun Qiao, Yinqi Long, Xicheng Yang, Le Zhou, Qifan Feng, 乔晞, Peifeng He, Zhixiu Li
This study identifies shared genetic architecture between physical activity and autoimmune diseases using GWAS data, revealing negative genetic correlations for active activities and positive for inactive ones, with key genes involved in T cell activation and lysosomal trafficking.
Journal of Clinical Rheumatology and Immunology · Jan 1, 2025Peer-reviewedGenetic & Genomic Medicine