Amyloid fibril structure of islet amyloid polypeptide by cryo-electron microscopy reveals similarities with amyloid beta
C. Roeder, T. Kupreichyk, L. Gremer, L. U. Schaefer, K. R. Pothula, R. B. Ravelli, D. Willbold, W. Hoyer, G. F. Schroeder
This study uses cryo-EM to reveal the structure of IAPP fibrils, showing similarities with Aβ polymorphs and linking genetic mutations to amyloid formation.
bioRxiv · Feb 11, 2020Biochemistry