Hindlimb Unloading Induces Bone Microarchitectural and Transcriptomic Changes in Murine Long Bones in an Age-Dependent Manner
S. J. Meas, G. M. Daire, M. J. Friedman, R. DeNapoli, P. Ghosh, J. N. Farr, H. Donahue
This study shows that hindlimb unloading causes age-dependent changes in bone microarchitecture and gene expression in mice, with younger mice showing senescence pathway activation and older mice showing mitochondrial dysfunction.
bioRxiv · Oct 9, 2023 · PreprintBioengineering