Live imaging of breast tumors shows macrophage-dependent induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination
V. P. Sharma, B. Tang, Y. Wang, G. S. Karagiannis, E. A. Xue, D. Entenberg, L. Borriello, A. Coste, C. L. Duran, R. J. Eddy, G. Kim, X. Ye, J. G. Jones, E. Grunblatt, N. Agi, , M. H. Oktay
The paper uses intravital imaging to show macrophage-induced cancer stem cells (CSCs) are enriched at TMEM doorways during metastasis, with CSCs comprising >60% of circulating tumor cells.
bioRxiv · Sep 18, 2020 · PreprintCancer Biology