Mutational impact of chronic alcohol use on stem cells in cirrhotic liver
M. Jager, E. Kuijk, R. Lieshout, M. Locati, N. Besselink, B. van der Roest, R. Janssen, S. Boymans, J. de Jonge, J. IJzermans, M. Doukas, M. Verstegen, R. van Boxtel, L. van der Laan, E. Cuppen
This study investigates the mutational impact of chronic alcohol use on liver stem cells in cirrhotic livers and finds no alcohol-specific mutational signatures but identifies enriched oncogenic mutations in cancer genes.
bioRxiv · Jul 11, 2019 · PreprintCancer Biology