Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth
D. J. L. Coleman, P. Keane, R. Luque-Martin, P. S. Chin, H. Blair, L. Ames, S. G. Kellaway, J. Griffin, E. Holmes, S. Potluri, S. A. Assi, J. H. Bushweller, O. T. Heidenreich, P. Cockerill, C. Bonifer
The paper identifies critical transcription factor regulons in FLT3-ITD+ AML by analyzing gene regulatory networks and shows their necessity for AML growth.
bioRxiv · Jul 18, 2023Cancer Biology