Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53
K. Wendrich, K. Gallant, S. Recknagel, S. Petroulia, S. Führer, K. Bezstarosti, R. O'Dea, J. Demmers, M. Gersch
This study identifies USP53 and USP54 as active deubiquitinases specific for K63-linked polyubiquitin, revealing their role in regulating tricellular junctions and correcting previous annotations of them as pseudo-enzymes.
bioRxiv · Jul 7, 2024Biochemistry