cell signaling & trafficking

The paper develops a computational model to show that Hsp70 chaperones only delay, not prevent, protein aggregation, depending on client-specific kinetic and thermodynamic properties.

The paper develops a computational model to explain how mechanical stimuli drive the formation of perinuclear actin structures through mechanosensitive actin polymerization.

NeuroDisco provides optogenetic stimulation to neuronal cultures to reduce synchronized bursting and enable functional analysis of neuronal activity.

This study shows HMGB1/CXCL12 heterocomplex activates CXCR4 to suppress Muller glia reprogramming into progenitor-like cells in chick retinas after injury.

This study identifies a high-order ion-coupling mechanism in EAAT transporters by showing that dEAAT2 can acquire Na+, H+, and K+ dependence through mutations, mimicking human hEAAT2's complex ion coupling.

This paper develops a surface-engineering strategy for edible microcarriers that enhances cell adhesion without limiting material choice, showing improved cell attachment on multiple polysaccharides and cell types.

The paper characterizes LOca-1, a calcium-activated arginyl-specific orthocaspase from Loki's Castle, showing its thermoactivity and structural conservation with plant metacaspases.

This study investigates brain-body interactions during food anticipation using multimodal physiological recordings, finding distinct changes in gastric and cortical responses linked to appetite and craving.

The paper investigates how intron lariats, especially those with transposable elements, trigger immune responses in cancer cells and shows that RNA editing and DBR1 depletion can be used to enhance anti-tumor effects.

This study identifies an early physiologic calcification process in mouse tracheal cartilage and reveals MGP deficiency causes additional mucosal calcification, explaining respiratory symptoms in Keutel syndrome.

The paper shows Rab10 and Arhgef7 interact to link vesicle transport and exocytosis, promoting axon extension by facilitating PPV insertion into the plasma membrane.

This study evaluates how fixation affects traction force microscopy measurements, finding that glutaraldehyde preserves live-cell-like metrics better than other protocols.

The paper identifies two competing pathways that influence neuronal firing patterns and hyperexcitability, showing how anti-seizure drugs selectively target these pathways.

The paper shows that adhesion assembly, F-actin accumulation, and force generation follow the same time evolution at adhesion sites, with F-actin retrograde flow being faster and not slowing over maturing adhesions.

The paper identifies protein-protein interactions in the core MCC of Arabidopsis thaliana using structural analysis, revealing new binding sites and interaction hierarchies.

The paper identifies BCAS3 as a novel interactor of WIPI2b that regulates its membrane association through interaction with PtdIns3P.

This study shows MmuPV1 and HPV16 E6 oncoproteins disrupt NF-κB signaling by increasing nuclear IKKα localization, suggesting a shared mechanism in papillomavirus persistence.

This study shows that older adults exhibit enhanced implicit motor adaptation only with consistent errors, not variable ones, suggesting error consistency is key for age-related adaptation.

This study identifies Lck and Fyn as essential Src family kinases required for T cell transendothelial migration through their regulation of PI3K signaling and cytoskeletal dynamics.

This study investigates changes in carotid body mitochondrial function in heart failure, finding decreased oxygen affinity and increased oxidative stress.

The paper identifies SEC16A/MAG5 as essential for ABA receptor homeostasis by mediating ER export and trafficking, impacting ABA signaling without affecting ABA levels.

This study identifies fss genes that regulate stalked cell morphogenesis and cell cycle progression independently of the flagellum in Caulobacter crescentus.

This study examines circulating CD4 regulatory T cells in Parkinson's disease and finds they are largely preserved in phenotype and function, though show reduced HELIOS expression in naive subsets.

The paper investigates experience-dependent plasticity in somatostatin interneurons and identifies two-pore potassium (K2P) channels as a mechanism underlying this plasticity.

This paper develops a framework to engineer oncolytic vaccinia virus to support off-the-shelf NK cells by aligning viral payloads with NK cell manufacturing limitations.

This study shows STMN2 regulates microtubule dynamics and axonal resilience in human motor neurons, linking cytoskeletal homeostasis to ALS pathology.

DIALECT enables synthetic cells to communicate with mammalian cells via DNA-programmed ligand release and engineered receptors, achieving specific signaling and logic gate functions.

This paper demonstrates a drug-free method using laser-induced vapor nanobubbles to create immunogenic whole-cell vaccines for bladder cancer, showing reduced tumor growth and immune activation.

This study shows that tissue-like viscoelastic substrates enhance muscle stem cell expansion by creating mechanical memory through focal adhesion stabilization and Rac-Akt signaling.