Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma
R. Salam, A. Saliou, F. Bielle, M. Bertrand, C. Antoniewski, C. Carpentier, A. Alentorn, L. Capelle, M. Sanson, E. Huillard, L. Bellenger, J. Guegan, I. Le Roux
This study shows that senescent cells in glioblastoma tumors contribute to progression and that removing them improves mouse survival, with similar patterns observed in patient tumors.
bioRxiv · May 18, 2022Cancer Biology