Functional analysis of the Nematostella Wnt/β-catenin destruction complex provides insight into the evolution of a critical regulatory module in a major metazoan signal transduction pathway
Hongyan Sun, Brian M. Walters, Radim Zidek, Mark Q. Martindale, Athula H. Wikramanayake
The paper investigates the evolution of the Wnt/β-catenin destruction complex in Nematostella vectensis, showing it functions similarly to bilaterians despite lacking conserved domains, suggesting an ancestral low-affinity binding mechanism.
bioRxiv · Oct 27, 2024 · PreprintEvolutionary Biology