Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes
Katherine Fodder, Megha N. Murthy, Patrizia Rizzu, Christina E. Toomey, Rahat Hasan, Jack Humphrey, Towfique Raj, Katie Lunnon, Jonathan S. Mill, Peter Heutink, Tammaryn Lashley, Conceição Bettencourt
This study identifies DNA methylation changes in FTLD subtypes, finding OTUD4 as a key gene with consistent expression dysregulation across subtypes.
Acta Neuropathologica · May 7, 2023Peer-reviewedNeuroscience