Differential clearance rate of proteins encoded on a self-amplifying mRNA vaccine in muscle and lymph nodes
Reo Kanechi, Tatsuya Shishido, Mana Tachikawa, Tomohiro Nishimura, Akihito Sawada, Hayato Okade, Daisuke Ishikawa, Hitoshi Yamaguchi, Marito Araki
This study investigates the differential clearance rates of spike protein and replicase components from a self-amplifying mRNA vaccine in muscle and lymph nodes, linking prolonged expression in lymph nodes to sustained antibody levels.
bioRxiv · Oct 7, 2024 · PreprintMolecular Biology