Physical epistatic landscape of antibody binding affinity
Rhys M. Adams, Justin B. Kinney, Aleksandra M. Walczak, Thierry Mora
The paper maps the epistatic landscape of antibody binding affinity using a null model and Tite-Seq data, showing that epistasis enhances the mutational accessibility of high-affinity antibodies.
bioRxiv · Dec 11, 2017 · PreprintBiophysics