Author

Riccardo Arnese

Telethon Institute Of Genetics And Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Organism:human· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Gennaro GambardellaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

1 paper

Recent·Most cited

ESMRank reveals a transferable axis of protein mutational constraint from overlapping variant effect assays

Riccardo Arnese, Gennaro Gambardella

ESMRank is a sequence-based predictor that integrates protein language models and physicochemical features to rank mutational constraint across proteins, outperforming existing methods and capturing disease-relevant variants.

Molecular Systems Biology · Oct 29, 2026Peer-reviewedBioinformatics