Inferring Cell Differentiation Dynamics with Unobserved Progenitors
William Howard-Snyder, Richard Zhang, Henri Schmidt, Michelle M. Chan, Benjamin J. Raphael
The paper introduces TROUPE, a framework to infer cell differentiation dynamics from lineage trees, allowing for unobserved progenitor types and providing better rate estimates than existing methods.
bioRxiv · Dec 12, 2025 · PreprintDevelopmental Biology