PERK/ATF3-dependent induction of GDE4 modulates intracellular lysophospholipid-PPARα/γ signaling
Keisuke Kitakaze, Risa Misumi, Saya Nagai, Hanif Ali, Yu Ukai, Daisuke Takamine, Naoya Takehara, Yume Iiboshi, Rikuto Miyoshi, Yuko Ito, Yoshihiro Sunada, Yasuhiro Takenouchi, Kazuhito Tsuboi, Tamotsu Tanaka, Yasuo Okamoto
This study identifies GDE4 as a PERK/ATF3-induced lysophospholipase that modulates intracellular LPA levels and PPARα/γ signaling in prostate cancer cells under ER stress.
bioRxiv · Aug 31, 2026 · PreprintMolecular Biology