Assumptions about frequency-dependent architectures of complex traits bias measures of functional enrichment
Shadi Zabad, Aaron P. Ragsdale, Rosie Sun, Yue Li, Simon Gravel
This study shows that assumptions in LDSC models can bias functional enrichment estimates in GWAS, suggesting the need for better calibration.
Genetic Epidemiology · Jun 22, 2021Peer-reviewedGenetics