Modelling of pH-dependence to develop a strategy for stabilising mAbs at acidic steps in production
Max Hebditch, Ryan Kean, Jim Warwicker
The paper develops a computational model to analyze pH-stability of antibodies and applies it to proteases, identifying design principles for acid-stable proteins.
Computational and Structural Biotechnology Journal · Jan 1, 2020Peer-reviewedBioinformatics