CD4+ T-cell epitope prediction by combined analysis of antigen conformational flexibility and peptide-MHCII binding affinity
T. P. Charles, D. L. Moss, P. Bhat, P. W. Moore, K. A. Nicholas, A. Bhattacharya, R. R. Mettu, S. J. Landry
The paper predicts CD4+ T-cell epitopes by combining antigen conformational flexibility and peptide-MHCII binding affinity, achieving 40% accuracy in epitope prediction.
bioRxiv · May 21, 2020Immunology