Discovering functionally important sites in proteins
M. Cagiada, S. Bottaro, S. Lindemose, S. M. Schenstrom, A. Stein, R. Hartmann-Petersen, K. Lindorff-Larsen
This paper introduces a machine learning method to predict functional sites in proteins by integrating sequence conservation and biophysical stability models, validated through experimental data on missense variants.
bioRxiv · Jul 14, 2022Biophysics