Author

S. N. Punnathanam

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Biophysics· 2

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:deep learning· 1 Organism:E. coli· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Kulshrestha· 2 shared K. G. Ayappa· 2 shared R. Roy· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBiophysics

A. Kulshrestha

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2 papers

Recent·Most cited

Cholesterol catalyzes unfolding in membrane inserted motifs of the pore forming protein cytolysin A

A. Kulshrestha, S. N. Punnathanam, R. Roy, K. G. Ayappa

This study shows cholesterol stabilizes an unfolded intermediate in the pore-forming toxin ClyA, lowering free energy barriers and enhancing pore formation kinetics.

bioRxiv · May 7, 2023Biophysics

Computing the mechanism of α-helix to β-sheet transition in proteins using the finitetemperature string method

A. Kulshrestha, S. N. Punnathanam, K. G. Ayappa

This paper uses the finite temperature string method with path collective variables to study the α-helix to β-sheet transition in a mini G-protein, revealing the intermediate steps and energy landscape of the structural change.

bioRxiv · Jul 21, 2022 · PreprintBiophysics